TRAF5TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.FunctionThe scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor protein family and contains a meprin and TRAF homology domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.InteractionsTRAF5 has been shown to interact with: ASK1, CD134, CD30, CD40, RANK TNFRSF13B, and TNFRSF14.