TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.
TRADD is an Signal transducing [adaptor protein|adaptor protein].
Function
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed [cell death] signaling and NF-κB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.[Image:TNF signaling.jpg|thumbnail|right|500px|Signaling pathway of Tumor [necrosis factor-alpha|TNF]-R1. Dashed grey lines represent multiple steps]