TIP39

Tuberoinfundibular peptide of 39 residues is a protein that in humans is encoded by the PTH2 gene.
TIP39 is related to parathyroid hormone and PTH-related protein and is a ligand for PTH receptor-2 .
The molecular interaction of TIP39 with the PTH2 receptor has been characterized in full 3D molecular detail, identifying among other residues, Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding
Expression of TIP39 has been linked to social interaction in both zebrafish and rats. In these species, mutations of TIP39 or its receptor lead to abnormal social behavior.