TFE3Transcription factor E3 is a protein that in humans is encoded by the TFE3 gene.FunctionTFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types.InteractionsTFE3 has been shown to interact with: E2F3, Microphthalmia-associated transcription factor, and Mothers against decapentaplegic homolog 3TranslocationsA proportion of renal carcinomas that occur in young patients are associated with translocations involving the TFE3 gene at chromosome Xp11.2 ''PRCC''