TFE3

Transcription factor E3 is a protein that in humans is encoded by the TFE3 gene.

Function

TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types.

Interactions

TFE3 has been shown to interact with:

E2F3,
Microphthalmia-associated transcription factor, and
Mothers against decapentaplegic homolog 3
Translocations

A proportion of renal carcinomas that occur in young patients are associated with translocations involving the TFE3 gene at chromosome Xp11.2 ''PRCC''