Seleucis of SyriaSeleucis of Syria was a region of the Seleucid Empire located in northern Syria. It was also known as the Syrian Tetrapolis,The four cities had been founded by Seleucus I Nicator;Antioch—named after his father and the largest city.Laodiceia—after his mother.Apameia—after his wife Apama.Seleuceia in Pieria—eponym of Seleucus.