In 1981, Hossain started practicing law in the District Judge Court. Then he joined as an advocate in the High Court Division in 1983. He was appointed as a deputy attorney generalin 1999. He was appointed as Additional Justice of the High Court Division on 22 February 2001 and two years later, on 22 February 2003, the permanent appointment was made. On 23 February 2011, he was appointed as the Appellate Division's Justice. He was the chairman of the search committee formed to form the Election Commission twice. Hossain is a strong supporter of country's Digital Security Act. In a verdict made on 6 March 2021, Hossain cautioned that there would be no consideration of bail for people who would tarnish the image of Bangladesh in any manner. He argued that this is because the first priority is the image of the country.