Suxibuzone

Suxibuzone is an analgesic used for joint and muscular pain. It is a prodrug of the non-steroidal anti-inflammatory drug phenylbutazone, and is commonly used in horses.

Synthesis

Suxibuzone is synthesized by the following method:
Phenylbutazone is hydroxymethylated with formaldehyde giving ~86% 4-butyl-4--1,2-diphenylpyrazolidine-3,5-dione . This is then esterified with succinic anhydride. to give.