Substituted phenylmorpholine


Substituted phenylmorpholines, or substituted phenmetrazines alternatively, are chemical derivatives of 2-phenylmorpholine or of the psychostimulant drug phenmetrazine.
Most such compounds act as releasers of monoamine neurotransmitters, and have stimulant effects. Some also act as agonists at serotonin receptors, and compounds with an N-propyl substitution act as dopamine receptor agonists.
A number of derivatives from this class have been investigated for medical applications, such as for use as anorectics or medications for the treatment of ADHD. Some compounds have also become subject to illicit use as designer drugs.

List of phenylmorpholines

SubstanceStructureCAS #
2-phenylmorpholine23972-41-0
2-phenyl-3-methylmorpholine 134-49-6
2-phenyl-3,4-dimethylmorpholine 634-03-7
2-phenyl-5-methylmorpholine 80123-66-6
2-phenyl-3-ethylmorpholine 100368-98-7
2-phenyl-3-methyl-4-ethylmorpholine 92196-09-3
2-phenyl-3,5-dimethylmorpholine 1218345-44-8
2-phenyl-3,6-dimethylmorpholine 92902-99-3
2-phenyl-5,5-dimethylmorpholine 42013-48-9
2-phenyl-3-methylmorpholin-5-one 5588-29-4
4-isopropyl-2-phenylmorpholine23222-62-0
Fenbutrazate4378-36-3
Morazone6536-18-1
2-Fluorophenmetrazine1533654-24-8
3-fluorophenmetrazine 1350768-28-3
4-Fluorophenmetrazine 1097796-73-0
3-fluorophenetrazine
3-chlorophenmetrazine 1097796-78-5
3-Methoxyphenmetrazine
2-Methylphenmetrazine1507705-48-7
3-methylphenmetrazine 1350768-41-0
4-methylphenmetrazine 1998216-41-3
4-methylphendimetrazine1445576-23-7
3-Iodophenmetrazine
2-morpholine
3,4-Methylenedioxyphenmetrazine
Naphthylmetrazine
2--3-methylmorpholine
2-morpholine 30914-89-7
Oxaflozane26629-87-8
Phenmetrazol1350768-19-2
N-Ethylphenmetrazol97630-98-3
--2--3,5,5-trimethylmorpholin-2-ol 106083-71-0
-2--3,5-dimethylmorpholin-2-ol 135306-39-7
PF-219,061710654-74-3
PF-592,379710655-15-5
OSU-6162156907-84-5
LPH-52641630-97-7
2-Methyl-3-phenylpiperidine70769-67-4
2-Phenyl-3-methyl-thiomorpholine
4-Methyl-5-phenyl-1,3-oxazolidine42794-92-3
Picilorex62510-56-9
Butyltolylquinuclidine
3-benzylmorpholine 7684-27-7
3-Benzhydrylmorpholine 93406-27-0

Additional phenylmorpholines and their activities as monoamine releasing agents have been described.