Strophanthus preussii grows as an evergreen liana up to long or a shrub up to tall, with a stem diameter up to. Its fragrant flowers feature a white to orangecorolla, red-striped or spotted on the inside. The corollas have very long tails up to long. Other vernacular names for the plant include "spider tresses" and "poison arrow vine".
Traditional medicinal uses of Strophanthus preussii include treatment of gonorrhoea and healing of sores. The plant has also been used as arrow poison.