Streptothricin
Streptothricins are a group of antibiotics in the aminoglycoside class. The first antibiotic in the group was isolated from Streptomyces lavendulae in 1942. It was later determined to be a mixture of closely related compounds, and is now known as nourseothricin. Although initial interest was positive because it appeared to be the first broad-spectrum antibiotic, meaning it was effective against both Gram-positive and Gram-negative bacteria, it never found clinical use due to toxicity. However, because of the increasing need for new antibiotics due to resistance to existing antibiotics, there is a current interest in developing new drugs based on the chemical scaffold of the streptothricins.