Streptogramin
Streptogramins are a class of antibiotics. They work as protein synthesis inhibitors.
Streptogramins are effective in the treatment of vancomycin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus, two of the most rapidly growing strains of multidrug-resistant bacteria. They fall into two groups: streptogramin A and streptogramin B. The two groups act synergistically. They are naturally produced in a 3:7 ratio; most formulations keep this ratio.
Members include:
- Quinupristin/dalfopristin, made by chemically modifying pristinamycin
- Pristinamycin, made by Streptomyces pristinaespiralis
- Virginiamycin, made by Streptomyces virginiae and others
- Linopristin/flopristin, made by semisynthesis. experimental streptogramin in clinical trials for the treatment of respiratory tract infections.
- Etamycin, a streptogramin B.