Spiperone


Spiperone, also known as spiroperidol and sold under the brand name Spiropitan ) is a typical antipsychotic of the butyrophenone family related to haloperidol. It is approved for clinical use in Japan as a treatment for schizophrenia.

Pharmacology

Pharmacodynamics

Spiperone interacts with various monoamine receptors.
Additionally, spiperone was identified by compound screening to be an activator of Ca2+ activated Cl− channels, thus a potential target for therapy of cystic fibrosis.

Chemistry

Derivatives

N-Methylspiperone is a derivative of spiperone that is used to study the dopamine and serotonin neurotransmitter system. Labeled with the radioisotope carbon-11, it can be used for positron emission tomography.