Spike
- 5Spike
- Alcohol (drug)
- Bottomless Pit (album)
- Cleat (shoe)
- Corporate Avenger
- Di-rect
- Golden Spike (disambiguation)
- Gorgeous Ladies of Wrestling
- Mickey Finn (drugs)
- Microsoft Word
- Money Money 2020
- Moondog Spike
- NAVAIR Spike
- Nail (fastener)
- Needle spiking
- Rail spike
- SPIKE algorithm
- SPIKES
- Screw spike
- South Kedah Expressway
- Southern Accents
- Spica
- Spike (2008 film)
- Spike (Agata album)
- Spike (Australian TV channel)
- Spike (DC Thomson)
- Spike (Dutch TV channel)
- Spike (Elvis Costello album)
- Spike (IDW Publishing)
- Spike (Puffy AmiYumi album)
- Spike (TV channel)
- Spike (Welsh guitarist)
- Spike (application)
- Spike (botany)
- Spike (character)
- Spike (company)
- Spike (database)
- Spike (dog actor)
- Spike (gridiron football)
- Spike (journalism)
- Spike (missile)
- Spike (music)
- Spike (musician)
- Spike (neuroscience)
- Spike (nickname)
- Spike (software development)
- Spike (stagecraft)
- Spike (surname)
- Spike (video game)
- Spike (volleyball)
- Spike Art Magazine
- Spike Dudley
- Spike Huber
- Spike Island (disambiguation)
- Spike Jones
- Spike Jonze
- Spike Lee
- Spike Magazine
- Spike Slawson
- Spike protein
- Spike strip
- Spike, Michigan
- Spiked (disambiguation)
- Spiker (disambiguation)
- Spikes (mascot)
- Spikes (surname)
- Spiking (fintech)
- Spindle (stationery)
- Spine (zoology)
- State College Spikes
- The Evolutionary Void
- The Spike (Broderick book)
- The Spike (disambiguation)
- The Spike (novel)
- Track spikes
- Tree spiking
- Voltage spike