Robert Spence

• Robert Spence (bishop), Archbishop of Adelaide
• Robert Spence (chemist), British chemist
• Robert Spence (British politician), MP for Berwick and Haddington
• Robert Spence (Canadian politician), political figure in Canada West
• Robert Spence (engineer), British engineer and information visualization expert
• Bob Spence, former Major League Baseball player
• Rob Spence (American football), American football coach