SPE
- Cell (microprocessor)
- Epitaxy
- Luminus (company)
- PowerPC e500
- Realm of the Mad God
- SPE Certified
- Sauber Petronas Engineering
- Serum protein electrophoresis
- Setiawangsa–Pantai Expressway
- Single-Pair Ethernet
- Societas Privata Europaea
- Society for Photographic Education
- Society of Petroleum Engineers
- Society of Plastics Engineers
- Society of Professional Engineers UK
- Société Parisienne d'Édition
- Solar particle event
- Solid phase extraction
- Sony Pictures
- Spe (planet)
- Special Police Establishment
- Special purpose entity
- Spes (disambiguation)
- Sporadic E propagation
- Stanford prison experiment
- The Sound Pattern of English