South Main Street Historic District
- East Main Street Historic District (disambiguation)
- Main Street Historic District (disambiguation)
- National Register of Historic Places listings in Bledsoe County, Tennessee
- National Register of Historic Places listings in Boone County, Kentucky
- National Register of Historic Places listings in Bulloch County, Georgia
- National Register of Historic Places listings in Grenada County, Mississippi
- National Register of Historic Places listings in Henderson County, Kentucky
- National Register of Historic Places listings in Mahoning County, Ohio
- National Register of Historic Places listings in Tarrant County, Texas
- National Register of Historic Places listings in Tipton County, Tennessee
- National Register of Historic Places listings in Umatilla County, Oregon
- National Register of Historic Places listings in Woodford County, Kentucky
- North Main Street Historic District (disambiguation)
- South Main Historic District (Bishopville, South Carolina)
- South Main Street Apartments Historic District
- South Main Street Commercial Historic District (Little Rock, Arkansas)
- South Main Street Commercial Historic District (disambiguation)
- South Main Street District (Middletown, Ohio)
- South Main Street District (disambiguation)
- South Main Street Historic District (Coventry, Rhode Island)
- South Main Street Historic District (Fayette, Missouri)
- South Main Street Historic District (Fond du Lac, Wisconsin)
- South Main Street Historic District (Geneva, New York)
- South Main Street Historic District (Janesville, Wisconsin)
- South Main Street Historic District (Joplin, Missouri)
- South Main Street Historic District (Kernersville, North Carolina)
- South Main Street Historic District (Memphis, Tennessee)
- South Main Street Historic District (Mount Morris, New York)
- South Main Street Historic District (Oregon, Wisconsin)
- South Main Street Historic District (Watkinsville, Georgia)
- South Main Street Historic District (Woonsocket, Rhode Island)
- South Main Street Residential Historic District (Little Rock, Arkansas)
- South Main Street Residential Historic District (Statesboro, Georgia)
- South Main Street Residential Historic District (disambiguation)
- South Main and South Elm Streets Historic District
- South Main and Washington Streets Historic District
- West Main Street Historic District (disambiguation)