Established around 1938 as a new primary routing as a spur from US 21 to Williams. In 1940, it was extended south to its current southern terminus at SC 64. In 1950, the entireroute was completelypaved.
South Carolina Highway 212 Connector is a connector route that exists just northwest of Bells Crossroads. It connects SC 64 with the SC 212 mainline just north of SC 212's southern terminus.