Sorting nexin


Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain or through protein–protein interactions with membrane-associated protein complexes Some members of this family have been shown to facilitate protein sorting.

Family members

In humans, sorting nexins are transcribed from the following genes:

Structure

Sorting nexins either consist solely of a PX domain or have a modular structure made up of the PX and additional domains.
A subgroup of sorting nexins possess a BAR domain at their C-terminus.
An example of a sorting nexin domain structure can be seen here for SNX1:
  1. NTD – N-terminal domain
  2. PX domain
  3. CTD – C-terminal BAR domain
Image:Sorting nexin schematic.png|thumb|left|450px|Schematic diagram of the 1D structures of a representative sorting nexin, the sorting nexin 1. NTD = N-terminal SNX domain, PX = PX domain, CTD = C-terminal BAR domain.