Small nucleolar RNA SNORD73

In molecular biology, snoRNA U73 is a non-coding RNA molecule which functions in the biogenesis of other small nuclear RNAs. This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA and also often referred to as a guide RNA.
snoRNA U73 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box and the D box. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.
U73 is encoded within the introns of ribosomal protein S3a and contains a 12 nucleotide region of complementarity to a conserved sequence in 28S ribosomal RNA. U73 has been demonstrated to function as a 2'-O-ribose methylation guide RNA for pre-28S rRNA.