Small nucleolar RNA SNORD49

In molecular biology, snoRNA U49 is a non-coding RNA molecule which functions in the modification of other small nuclear RNAs. This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA and also often referred to as a guide RNA.
snoRNA U49 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box and the D box. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.
U49 was identified by cloning from HeLa cells and is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA residue C4426. In the human genome there are two related copies of U45 which are encoded in the introns of the same host gene.