Small nucleolar RNA SNORD48

In molecular biology, SNORD48 is a non-coding RNA molecule which functions in the modification of other small nuclear RNAs. This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA and also often referred to as a guide RNA.
U48 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box and the D box. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.
This snoRNA was originally cloned from HeLa cells and experimentally verified by northern blotting. SNORD48 is predicted to guide the
2'O-ribose methylation of 28S rRNA C2279. In the human genome this snoRNA is located in the introns of the same host gene as another C/D box snoRNA U52.