Small nucleolar RNA SNORD37

In molecular biology, SNORD37 is a non-coding RNA molecule which functions in the modification of other small nuclear RNAs. This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA and also often referred to as a guide RNA.
snoRNA U37 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box and the D box. Most of the members of the C/D box family function in directing site-specific 2'-O-methylation of substrate RNAs.
This snoRNA was originally identified by computational screening of vertebrate genomes for conserved C/D box motifs within intronic regions and expression experimentally verified by northern blotting.
The mouse orthologue was identified.
SNORD37 is predicted to guide the 2'O-ribose methylation of the 28S ribosomal RNA at residue A3697.