Small nucleolar RNA SNORD32

In molecular biology, snoRNA U32 is a non-coding RNA molecule which functions in the modification of other small nuclear RNAs. This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA and also often referred to as a guide RNA.
snoRNA U32 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box and the D box. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.
U32 is encoded within intron 2 of the ribosomal protein L13 gene in human and mouse and is predicted to guide the 2'O-ribose methylation of both 18S ribosomal RNA residue G1328 and 28S rRNA residue A1511. U32A share the same host gene with the C/D box snoRNAs U33, U34 and U35A.