Small nucleolar RNA SNORD25

In molecular biology, snoRNA U25 is a non-coding RNA molecule which functions in the biogenesis of other small nuclear RNAs. This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA and also often referred to as a guide RNA.
U25 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box and the D box. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.
U25 is found in gene clusters in plants and within the U22 snoRNA host gene in mammals. U25 is thought to as a 2'-O-ribose methylation guide for ribosomal RNA. This RNA has also been named snoRNA R73 in some plants.