Small nucleolar RNA R38

In molecular biology, Small nucleolar RNA R38 is a non-coding RNA molecule which functions in the modification of other small nuclear RNAs. This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA and also often referred to as a guide RNA.
snoRNA R38 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box and the D box. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.
snoRNA R38 has been identified in human, yeast, Arabidopsis thaliana
and Oryza sativa
. snoRNA R38 guides the methylation of 2'-O-ribose sites in 28S rRNA.