Simcoe, MissouriSimcoe is an unincorporated community in northeastern McDonald County, in the U.S. state of Missouri. Simcoe is located along Missouri Route 76 between Longview and Bethlehem.HistoryA post office called Simcoe was established in 1893, and remained in operation until 1909. According to tradition, the community took its name from a local cooperative of the same name.