Sikiè was one of those places where the Askia dynasty settled after the fall of the Songhai Empire in 1591. In the mid-17th century, Sikié was part of the dominion of Ginde Marieizé, the ruler of Namaro.
The inhabitants are predominantly farmers who grow cassava, pumpkins and rice. These commodities are mostly sold at to the neighboring towns of Namaro, Boubon and Karma. In 2013, a group of investors from Malaysia planned to establish a 766 hectares industrial livestock production complex in Sikié and neighboring towns of Yonkoto.