Setoperone


Setoperone is a compound that is a ligand to the 5-HT2A receptor. It can be radiolabeled with the radioisotope fluorine-18 and used as a radioligand with positron emission tomography. Several research studies have used the radiolabeled setoperone in neuroimaging for the studying neuropsychiatric disorders, such as depression or schizophrenia. The drug was first described by at least 1984.

Chemistry

Synthesis

The starting material is called 6--7-methyl-2,3-dihydro-thiazolopyrimidin-5-one, . Halogenation of this with hydrobromic acid in acetic acid gives . Sn2 alkylation with 4-piperidine under Finkelstein reaction conditions affords setoperone.