Sergio Santos

• Sergio Santos (baseball), American baseball player
• Sérgio Santos (volleyball), also known as Serginho or Escadinha, Brazilian volleyball player
• Sérgio Santos (footballer, born 1994), Brazilian football forward for Houston Dynamo FC
• Sérgio Santos (footballer, born 1998), Portuguese football forward for Petro Luanda
• Sergio Santos (footballer, born 2001), Spanish football right-back for Gimnàstic Tarragona