Senator Lewis
- Albert B. Lewis
- Bob Lewis (Washington politician)
- Bonnie Titcomb Lewis
- Brian J. Lewis
- Dave Lewis (politician)
- David John Lewis
- Dixon Hall Lewis
- Earl Ramage Lewis
- H. Craig Lewis
- Helmar Lewis
- J. Hamilton Lewis
- James Lewis (Indiana politician)
- James T. Lewis
- Jason Lewis (Massachusetts politician)
- Jerry Lewis (Arizona politician)
- John F. Lewis
- John Lewis (California politician)
- John W. Lewis Jr.
- John Wood Lewis Sr.
- Loran L. Lewis
- Morgan Lewis (governor)
- Robert S. Lewis
- Thomas Lewis (Kentucky politician)
- William Lewis (New York politician)