Senator Hughes
- Bryan Hughes (politician)
- Charles Hughes (representative)
- Charles J. Hughes Jr.
- Dan Hughes (Nebraska politician)
- Dudley Mays Hughes
- Edward J. Hughes
- Edward J. Hughes Jr.
- Francis Wade Hughes
- Harold Hughes
- Harry Hughes
- Henry Hughes (sociologist)
- James A. Hughes
- James H. Hughes
- Jerome M. Hughes
- Jim Hughes (politician)
- John H. Hughes (politician)
- Mildred Barry Hughes
- Ralph M. Hughes
- Shelley Hughes
- Teresa Patterson Hughes
- Vincent Hughes
- William Hughes (U.S. senator)