Senator Clark
- Alan Clark (Arkansas politician)
- Amos Clark Jr.
- Ben Clark (politician)
- Bennett Champ Clark
- Chase A. Clark
- Clarence D. Clark
- Daniel Clark (New Hampshire politician)
- David Worth Clark
- Dick Clark (senator)
- Edward Clark (governor)
- Eugene Clark (politician)
- Franklin Clark
- Henry A. Clark (New York politician)
- Henry Alden Clark
- Henry Toole Clark
- Irma Clark-Coleman
- J. Murray Clark
- James Clark (Kentucky politician)
- James Clark Jr.
- James S. Clark
- Jim Clark (offensive lineman)
- John Bullock Clark
- John Clark (Minnesota politician)
- Joseph Clark (New York politician)
- Joseph S. Clark Jr.
- Katherine Clark
- Martha Fuller Clark
- Merritt Clark
- Myron H. Clark
- Nancy Randall Clark
- Orville Clark
- Perry B. Clark
- Satterlee Clark Jr.
- Senator Clarke (disambiguation)
- Sir George Clark, 1st Baronet
- Sir George Clark, 3rd Baronet
- Tarryl Clark
- Ted D. Clark
- William A. Clark
- William Clark (politician, born 1811)
- William G. Clark
- William Moore Wallis Clark
- William Walter Clark
- Wilson Hart Clark
- Zenas Clark