Semaphorin 3E

Semaphorin 3E is a protein that in humans is encoded by the SEMA3E gene.

Function

Semaphorin are a large family of conserved secreted and membrane associated proteins which possess a semaphorin domain and a PSI domain in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some containing plexin proteins.
This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene..