Second cabinet of John Vorster
| Ministry/Portfolio | Minister/Incumbent | Start | End |
| Prime Minister | Johannes Vorster | 18 May 1970 | 29 April 1974 |
| Minister of Foreign Affairs | Hilgard Muller | 18 May 1970 | 29 April 1974 |
| Minister of Defense | Pieter Botha | 18 May 1970 | 29 April 1974 |
| Minister of Finance | Nicolaas Diederichs | 18 May 1970 | 29 April 1974 |
| Minister of Home Affairs | Marais Viljoen Theo Gerdener Connie Mulder | 18 May 1970 | 29 April 1974 |
| Minister of Immigration | Connie Mulder Piet Koornhof | 18 May 1970 1972 | 1972 29 April 1974 |
| Minister of Information | Connie Mulder | 18 May 1970 | 29 April 1974 |
| Minister of Justice and Prisons | Petrus Cornelius Pelser | 18 May 1970 | 29 April 1974 |
| Minister of Police | Lourens Muller | 18 May 1970 | 29 April 1974 |
| Minister of Transport | Ben Schoeman | 18 May 1970 | 29 April 1974 |
| Minister of Labour | Marais Viljoen | 18 May 1970 | 29 April 1974 |
| Minister of Mining | Carel de Wet Piet Koornhof | 18 May 1970 | 29 April 1974 |
| Minister of Sports and Recreation | Frank Waring Piet Koornhof | 18 May 1970 | 29 April 1974 |
| Minister of the Economy | Lourens Muller | 18 May 1970 | 29 April 1974 |
| Minister of Bantu Administration and Bantu Education | M. C. Botha | 18 May 1970 | 29 April 1974 |
| Minister of National Education | Johannes van der Spuy | 18 May 1970 | 29 April 1974 |
| Minister of Public Works | Blaar Coetzee Abraham du Plessis | 18 May 1970 | 29 April 1974 |
| Minister of Agriculture | D. C. H. Uys Hendrik Schoeman | 18 May 1970 1972 | 1972 29 April 1974 |
| Minister of Water Affairs and Forestry | Fanie Botha | 18 May 1970 | 29 April 1974 |
| Minister of Welfare and Pensions | Connie Mulder Johannes van der Spuy | 18 May 1970 | 29 April 1974 |
| Minister of Post, Telegraphs and Telecommunication | Marais Viljoen | 18 May 1970 | 29 April 1974 |
| Minister of Health | Carel de Wet Schalk van der Merwe | 18 May 1970 1972 | 1972 29 April 1974 |
| Minister of the Environment | Jannie Loots | 1973 | 29 April 1974 |
| Minister of Planning and Statistics | Jannie Loots | 18 May 1970 | 29 April 1974 |
| Minister of Tourism and Minister of Indian Affairs | Frank Waring Owen Horwood | 18 May 1970 1972 | 1972 29 April 1974 |
| Minister of Coloured Affairs and Matters of the Rehoboth Homeland | Jannie Loots Schalk van der Merwe | 18 May 1970 1972 | 1972 29 April 1974 |