| Office | Name | Date |
Prime Minister
First Lord of the Treasury
Leader of the House of Lords | Edward Smith-Stanley, 14th Earl of Derby | 21 February 185811 June 1859 |
Chancellor of the Exchequer
Leader of the House of Commons | Benjamin Disraeli | 26 February 1858 |
| Parliamentary Secretary to the Treasury | Sir William Jolliffe | 2 March 1858 |
| Financial Secretary to the Treasury | George Alexander Hamilton | 2 March 1858 |
| Financial Secretary to the Treasury | Sir Stafford Northcote | 21 January 1859 |
| Junior Lords of the Treasury | Lord Henry Lennox | 1 March 185814 March 1859 |
| Junior Lords of the Treasury | Thomas Edward Taylor | 1 March 185811 June 1859 |
| Junior Lords of the Treasury | Henry Whitmore | 1 March 185811 June 1859 |
| Junior Lords of the Treasury | Peter Blackburn | 15 March 185911 June 1859 |
| Lord Chancellor | Frederic Thesiger, 1st Baron Chelmsford | 26 February 1858 |
| Lord President of the Council | James Gascoyne-Cecil, 2nd Marquess of Salisbury | 26 February 1858 |
| Lord Privy Seal | Charles Philip Yorke, 4th Earl of Hardwicke | 26 February 1858 |
| Secretary of State for the Home Department | Spencer Horatio Walpole | 26 February 1858 |
| Secretary of State for the Home Department | Thomas H. Sotheron-Estcourt | 3 March 1859 |
| Under-Secretary of State for the Home Department | Gathorne Hardy | 26 February 1858 |
| Secretary of State for Foreign Affairs | James Howard Harris, 3rd Earl of Malmesbury | 26 February 1858 |
| Parliamentary Under-Secretary of State for Foreign Affairs | William Robert Seymour Vesey Fitzgerald | 26 February 1858 |
| Secretary of State for War | Jonathan Peel | 26 February 1858 |
| Under-Secretary of State for War | Charles Hardinge, 2nd Viscount Hardinge | 8 March 1858 |
| Under-Secretary of State for War | James St Clair-Erskine, 3rd Earl of Rosslyn | 3 March 1859 |
| Surveyor-General of the Ordnance | vacant | — |
| Secretary of State for the Colonies | Lord Stanley | 26 February 1858 |
| Secretary of State for the Colonies | Sir Edward Bulwer-Lytton | 5 June 1858 |
| Under-Secretary of State for the Colonies | Henry Herbert, 4th Earl of Carnarvon | 26 February 1858 |
| Secretary of State for India | Lord Stanley | 2 September 1858 |
| Under-Secretary of State for India | Henry James Baillie | 30 September 1858 |
| First Lord of the Admiralty | Sir John Pakington | 8 March 1858 |
| First Secretary of the Admiralty | Henry Thomas Lowry Corry | 9 March 1858 |
| Civil Lord of the Admiralty | Lord Lovaine | 8 March 1858 |
| Civil Lord of the Admiralty | Frederick Lygon | 9 March 1859 |
| President of the Board of Control | Edward Law, 1st Earl of Ellenborough | 6 March 1858 |
| President of the Board of Control | Lord Stanley | 5 June 1858 |
| Joint Secretary to the Board of Control | Henry James Baillie | 6 March 1858 |
| President of the Board of Trade | Joseph Warner Henley | 26 February 1858 |
| President of the Board of Trade | Richard John Hely-Hutchinson, 4th Earl of Donoughmore | 3 March 1859 |
| Vice-President of the Board of Trade | Richard John Hely-Hutchinson, 4th Earl of Donoughmore | 6 April 1858 |
| Vice-President of the Board of Trade | Lord Lovaine | 3 March 1859 |
| First Commissioner of Works | Lord John Manners | 26 February 1858 |
| Vice-President of the Committee on Education | Charles Bowyer Adderley | 12 March 1858 |
| President of the Board of Health | Charles Bowyer Adderley | 8 March 1858 |
| Chief Secretary for Ireland | Lord Naas | 4 March 1858 |
| Lord Lieutenant of Ireland | Archibald William Montgomerie, 13th Earl of Eglinton | 8 March 1858 |
| Chancellor of the Duchy of Lancaster | James Graham, 4th Duke of Montrose | 26 February 1858 |
| Paymaster General | Richard John Hely-Hutchinson, 4th Earl of Donoughmore | 6 April 1858 |
| Paymaster General | Lord Lovaine | 3 March 1859 |
| President of the Poor Law Board | T.H.S. Sotheron Estcourt | 6 March 1858 |
| President of the Poor Law Board | Earl of March | 7 March 1859 |
| Parliamentary Secretary to the Poor Law Board | Frederick Winn Knight | 12 March 1858 |
| Postmaster-General | Charles Edward Abbott, 2nd Baron Colchester | 13 March 1858 |
| Attorney General | Sir Fitzroy Kelly | 26 February 1858 |
| Solicitor General | Sir Hugh Cairns | 26 February 1858 |
| Judge Advocate General | John Mowbray | 13 March 1858 |
| Lord Advocate | John Inglis | 1 March 1858 |
| Lord Advocate | Charles Baillie | 10 July 1858 |
| Lord Advocate | David Mure | 15 April 1859 |
| Solicitor General for Scotland | Charles Baillie | 17 March 1858 |
| Solicitor General for Scotland | David Mure | 12 July 1858 |
| Solicitor General for Scotland | George Patton | 3 May 1859 |
| Attorney General for Ireland | James Whiteside | February 1858 |
| Solicitor General for Ireland | Henry George Hughes | February 1858 |
| Solicitor General for Ireland | Edmund Hayes | 1859 |
| Lord Steward of the Household | Brownlow Cecil, 2nd Marquess of Exeter | 26 February 1858 |
| Lord Chamberlain of the Household | George John Sackville-West, 5th Earl De La Warr | 26 February 1858 |
| Master of the Horse | Henry Charles Fitzroy Somerset, 8th Duke of Beaufort | 26 February 1858 |
| Treasurer of the Household | Lord Claud Hamilton | 26 February 1858 |
| Comptroller of the Household | George Weld-Forester | 26 February 1858 |
| Captain of the Gentlemen-at-Arms | Henry John Chetwynd-Talbot, 18th Earl of Shrewsbury | 26 February 1858 |
| Captain of the Yeomen of the Guard | William Lennox Lascelles FitzGerald-de Ros, 23rd Baron de Ros | 17 March 1858 |
| Master of the Buckhounds | John William Montagu, 7th Earl of Sandwich | 26 February 1858 |
| Chief Equerry and Clerk Marshal | Charles Colville, 1st Viscount Colville of Culross | 26 February 1858 |
| Mistress of the Robes | The Duchess of Manchester | 26 February 1858 |
| Lords in Waiting | James Grimston, 2nd Earl of Verulam | 26 February 185811 June 1859 |
| Lords in Waiting | George Holroyd, 2nd Earl of Sheffield | 26 February 185811 June 1859 |
| Lords in Waiting | William Drummond, 7th Viscount Strathallan | 26 February 185811 June 1859 |
| Lords in Waiting | Henry Hepburne-Scott, 7th Lord Polwarth | 26 February 185811 June 1859 |
| Lords in Waiting | Edward Crofton, 2nd Baron Crofton | 26 February 185811 June 1859 |
| Lords in Waiting | William Bateman-Hanbury, 2nd Baron Bateman | 26 February 185811 June 1859 |
| Lords in Waiting | Richard Somerset, 2nd Baron Raglan | 26 February 185811 June 1859 |