Second Avenue
- 2nd Avenue (TV channel)
- 2nd Avenue (album)
- 2nd Avenue Lofts
- 2nd Street (disambiguation)
- Arterial roads in Whitehorse, Yukon
- IRT Second Avenue Line
- Irving and 2nd Avenue station
- M15 (New York City bus)
- Nashville, Tennessee
- Neighborhoods of Albany, New York
- On Second Avenue
- Second Avenue (Brooklyn)
- Second Avenue (IND Sixth Avenue Line)
- Second Avenue (Manhattan)
- Second Avenue (Pittsburgh)
- Second Avenue (album)
- Second Avenue (song)
- Second Avenue Deli
- Second Avenue Railroad
- Second Avenue Subway