The first written mention of Sebuzín is from 1251. Until 1580, it was owned by a local noble family who called themselves Barons of Sebuzín. After 1580, the village was divided into two parts that had different owners. The first part belonged to the Litoměřice estate and later to the Lovosice estate. The second part belonged to the Kamýk estate. The sovereign municipality of Sebuzín was established in 1848, but in 1980, it was merged with Ústí nad Labem.
The main historical landmark of Sebuzín is the Chapel of Saint Vincent Ferrer. It was built in the late Baroque style in 1745. There is a sculpture in the niche and an iron bell in the pinnacle.