Sebastapistes fowleri is one of the tiniest scorpionfishes, measuring about 2–3 cm in standard length in published records and photographs. It is typically orange to red with speckledwhite and blackmarkings, giving it a mottled appearance that blends well with coral and rubble. The species has proportionally large eyes and a somewhat flattened body adapted for camouflage within reef structures. Like other members of Scorpaenidae, Sebastapistes fowleri possesses venomous fin spines used for defense, and it is a small reef predator that feeds on tiny fishes and invertebrates.