Seasonality Modifies Methylation Profiles in Healthy People
Seasonality Modifies Methylation Profiles in Healthy People is a scholarly work by Valentina Fiano, Fulvio Ricceri, Carlotta Sacerdote, Paolo Vineis, Morena Trevisan, Francesca Fasanelli, and Chiara Scoccianti, published in 2014 in ''PLOS One''. The main subjects of the publication include gene, physiology, genetics, DNA methylation, pyrosequencing, methylation, glossary of medicine, biology, seasonality, epigenetics, and CpG site. The authors investigated the effect of seasonality on basal methylation by testing methylation levels in the long interspersed nucleotide element-1 (LINE-1) and in two cancer-related genes (RASSF1A and MGMT) of 88 healthy male heavy smokers involved in an Italian randomized study; at enrolment the subjects donated a blood sample collected in different months.