SCI
- Ford Duratec engine
- Metcalf Center for Science and Engineering
- Paramillo Airport
- Pennsylvania Department of Corrections
- SCI (calculator mode)
- SCIS (disambiguation)
- SCi Games
- Safari Club International
- Sanmina Corporation
- Scalable Coherent Interface
- Schistosomiasis Control Initiative
- Sci (journal)
- Science Channel
- Science Citation Index
- Science of Creative Intelligence
- Scientific Computing and Imaging Institute
- Seamen's Church Institute of New York and New Jersey
- Sensitive Compartmented Information
- Serial communication interface
- Service Civil International
- Service Corporation International
- Shipping Corporation of India
- Sierra Creative Interpreter
- Silverthorn Collegiate Institute
- Sister Cities International
- Site of Community Importance
- Society of Chemical Industry
- Solar Cookers International
- Southern Careers Institute
- Space Competitiveness Index
- Special Criminal Investigation
- Spinal cord injury
- Sport Club Internacional
- Strategic Computing Initiative
- Summer Camp Island
- Supreme Court of India
- System call
- The String Cheese Incident
- WMSCI