Sargocentron spiniferum is the largest squirrelfish in its range and can reach up to in length and in weight. A more common length for S. spiniferum is. The body is oval and laterally compressed. The head has a pointed snout and large eyes, being largely nocturnal. The basic colour is bright red. It has silver scale margins, a spinous dorsal fin and a large deep red patch just behind the eyes. The lower jaw protrudes beyond the upper jaw. It bears a very long preopercle spine. The anal and ventralfins are yellowish. The caudal fin is clearly bifid.