Santo (surname)
Santo is the surname of:
- Akiko Santō, Japanese politician
- Anthony Santo, Italian-American murderer
- Audrey Santo, or Little Audrey, through whom miracles were said to have happened
- Damián de Santo, Argentine actor
- Guillermo Santo, Argentine footballer
- Hildi Santo-Tomas, American interior designer and television personality
- Ron Santo, American baseball player and broadcaster