| # | Name | Image | Size | Year Designated | Description |
| 1 | Jackson Square | | 8 Blocks, 82 Parcels | 1972 | Earliest surviving commercial area features commercial and mixeduse buildings erected in the 1850s to 1860s. |
| 2 | Webster Street | | 3 Blocks, 25 Parcels | 1981 | Residential district in the Western Addition features a unified collection in the Italianate style. |
| 3 | Northeast Waterfront | | 9 Blocks, 52 Parcels | 1983 | Commercial and industrial district reflects waterfront storage and maritime activities, from the Gold Rush to World War II. |
| 4 | Alamo Square | | 16 Blocks, 281 Parcels | 1984 | Residential district features richly ornamented houses in a range of Victorian- and Edwardian-era styles. |
| 5 | Liberty Hill Historic District | | 10 Blocks, 298 Parcels | 1985 | Victorian-era residences designed primarily in the Italianate, Stick, and Queen Anne styles in Mission District. |
| 6 | Telegraph Hill | | 6 Blocks, 90 Parcels | 1986 | Eclectic hillside district features the largest concentration of pre-1870s buildings accessible only via narrow pedestrian-only lanes and staircases. |
| 7 | Blackstone Court | | 1 Block, 4 Parcels | 1987 | Residential district centered around the now-filled Washerwoman's Lagoon on a pre-Gold Rush trail of pre-1906 development in the Marina District. |
| 8 | South End | | 6 Blocks, 84 Parcels | 1990 | Industrial and warehouse of brick and reinforced concrete single- and multi-story warehouses erected between 1906 and 1929. |
| 9 | Bush Street–Cottage Row | | 2 Blocks, 23 Parcels | 1991 | Residential buildings of flat front Italianate and Stick design in Japantown. |
| 10 | Civic Center | | 15 Blocks, 61 Parcels | 1996 | Monumental Beaux Arts Classical design institutional buildings flanking a central open space. |
| 11 | Dogpatch | | 9 Blocks, 131 Parcels | 2003 | Oldest enclave of industrial workers’ housing in San Francisco located east of Potrero Hill. |
| 12 | Market Street Masonry | | 5 Blocks, 8 Parcels | 2013 | Discontiguous district of 8 structures built between 1911 and 1925. Each building is constructed of reinforced concrete or a combination of brick and reinforced concrete. All are designed by San Francisco master architects. |
| 13 | Duboce Park | | 4 Blocks, 90 Parcels | 2013 | Residential district featuring well-preserved Victorian- and Edwardian-era homes, many in the Queen Anne style. The district includes Duboce Park. |