SU-11739

SU-11739 is an experimental monoamine oxidase inhibitor that was never marketed.
It is a dual or non-selective irreversible monoamine oxidase A and monoamine oxidase B inhibitor, with preference for inhibition of MAO-B over MAO-A. It is less selective for MAO-B inhibition than AGN-1135 or rasagiline. In addition to its MAOI activity, SU-11739 has been reported to have strong activity as a catecholamine releasing agent. Similarly to rasagiline, but unlike selegiline and desmethylselegiline, SU-11739 is not a monoaminergic activity enhancer.
The drug is the racemic N-methylated analogue of rasagiline. It is also a ring-cyclized analogue of pargyline with about 20times the MAOI potency of pargyline.
SU-11739 was discovered before rasagiline and was patented in 1965.