SSE
- Enema
- Line 2 Bloor–Danforth
- Michael Young, Baron Young of Dartington
- OVO Hydro
- Residual sum of squares
- SPARQL Syntax Expressions
- SQL Server Express
- SSE Arena, Belfast
- SSE plc
- School of Social Ecology
- Scottish Standard English
- Searchable symmetric encryption
- Secure service edge
- Seed Savers Exchange
- Sensitive site exploitation
- Server-sent events
- Seven Seas Entertainment
- Shanghai Stock Exchange
- Shenzhen Stock Exchange
- Shin Seiki Evangelion
- Shipping industry of China
- Shoreham-by-Sea railway station
- Sign Supported English
- Silk screen effect
- Simple Sharing Extensions
- Sins of a Solar Empire
- Sizzle (selector engine)
- Skyrim Special Edition
- Small-scale enterprise
- Social Software Engineering
- Social and solidarity economy
- Society for Scientific Exploration
- Society for the Study of Evolution
- Solid-state electrolyte
- Somalia Stock Exchange
- South-southeast
- Southern Star Endemol
- Spaceship Earth (Epcot)
- Standard Singapore English
- Steady-state economy
- Stockholm School of Economics
- Streaming SIMD Extensions
- Stredoslovenská energetika
- Submerged signal ejector
- Subspace Emissary
- Substantial shareholdings exemption
- Supply-side economics
- Sustainable Stock Exchanges Initiative
- Symbiosis School of Economics
- Wembley Arena