List of highways numbered 180
- A180 highway (Russia)
- A180 road (Malaysia)
- Alabama State Route 180
- Arizona State Route 180A
- Arkansas Highway 180
- California State Route 180
- Farm to Market Road 180
- Georgia State Route 180
- Hawaii Route 180
- Illinois Route 180
- Interstate 180 (disambiguation)
- Japan National Route 180
- K-180 (Kansas highway)
- Kentucky Route 180
- M-180 (Michigan highway)
- Maine State Route 180
- Maryland Route 180
- Mexican Federal Highway 180
- Missouri Route 180
- National Route 180 (Costa Rica)
- New Brunswick Route 180
- New Jersey Route 180
- New York State Route 180
- North Carolina Highway 180
- North–South Port Link
- Ohio State Route 180
- Oregon Route 180
- Prince Edward Island Route 180
- Puerto Rico Highway 180
- Pyrenees Highway
- R180 road (Ireland)
- Tennessee State Route 180
- Texas State Highway 180
- Texas State Highway Spur 180
- U.S. Route 180
- Utah State Route 180
- Virginia State Route 180
- West Virginia Route 180
- Winnipeg Route 180
- Wisconsin Highway 180