SRS
- 1st Strategic Reconnaissance Squadron
- Cirrus SRS
- European Centre for Disease Prevention and Control
- SRS (sailing)
- SRS Cinemas
- SRS Labs
- Savannah River Site
- Savez Radio-Amatera Srbije
- Scoliosis Research Society
- Sea Ranger Service
- Sea Research Society
- Security Response Section
- Selhurst railway station
- Sender Rewriting Scheme
- Sequence Retrieval System
- Serbian Radical Party
- Sex reassignment surgery
- Shock response spectrum
- Silver–Russell syndrome
- Simple random sample
- Slipping rib syndrome
- Slow-reacting substance of anaphylaxis
- Snyder–Robinson syndrome
- Social Reporting Standard
- Social Responsiveness Scale
- Socialist Revolutionary Party
- Society for Renaissance Studies
- Software requirements specification
- Somatostatin receptor scintigraphy
- Sound Retrieval System
- Southwick Regional School
- Space research service
- Spaced repetition
- Spanish Riding School
- Spatial reference system
- Special Repair Service
- Sperry Rail Service
- Spontaneous Raman spectroscopy
- Spontaneous reporting system
- Sri Ram Sena
- Standard RPG System
- Stanford Research Systems
- Stealth Recon Scout
- Stereotactic radiosurgery
- Stimulated Raman spectroscopy
- Stratified sampling
- Street Racing Syndicate
- String rewriting system
- Strontium sulfide
- Suffolk Records Society
- Supplementary Restraint System
- Synchrotron Radiation Source