SPT
- Sandpoint station
- Septic pelvic thrombophlebitis
- Serine C-palmitoyltransferase
- Shortest-path tree
- Single-particle tracking
- Skin prick test
- Social penetration theory
- Society for Philosophy and Technology
- Sony Pictures Television
- South Pole Telescope
- Spotswood railway station
- Springhurst railway station
- Spt function
- Standard penetration test
- Stationary Plasma Thruster
- Stochastic portfolio theory
- Stockport railway station
- Strathclyde Partnership for Transport
- Substantial Presence Test
- Sunpentown
- Super Powered Tracer
- Symmetry-protected topological order