SPO
- Erik Spoelstra
- Miami Heat
- Party of Civic Rights
- SPO Rouen Basket
- SPOC (disambiguation)
- Saint Paul's Outreach
- Sankt Peter-Ording
- Scholarly Publishing Office
- Secondary phosphine oxide
- Seoul Philharmonic Orchestra
- Serbian Renewal Movement
- SharePoint
- Social Democratic Party of Austria
- Socialist Party of Ontario
- Spo11
- Strengthening Participatory Organization
- Strong Pareto optimum
- Supreme Prosecutors' Office of the Republic of Korea