SPI
- Abraham Lincoln Capital Airport
- C (programming language)
- Cameron County, Texas
- Indian Protection Service
- Java (programming language)
- PostgreSQL
- SCSI Parallel Interface
- SPI 200 futures contract
- SQL
- Security Parameter Index
- Sediment Profile Imagery
- Serial Peripheral Interface
- Service provider interface
- Simulations Publications, Inc.
- Single-point injection
- Sisters of Perpetual Indulgence
- Social Progress Imperative
- Social Progress Index
- Society for Philosophical Inquiry
- Society of the Plastics Industry
- Software Patent Institute
- Software in the Public Interest
- Sony Pictures Imageworks
- South Padre Island, Texas
- Spy (disambiguation)
- St. Pascual Institution
- St. Paul's Institution
- Stateful firewall
- Stream Processors, Inc
- Superintendent of Public Instruction
- Sustainable Preservation Initiative
- Sveriges Pensionärers Intresseparti
- Swiss Performance Index
- System Packet Interface
- Texas